Panely s využitím molekulárně inverzních sond

Panely s využitím molekulárně inverzních sond

Co kdybyste měli hotový panel ještě před obědem?

• Mimořádně rychlé extrémně jednoduché TERGETED PANELS
• Předdefinované panely a customs panely do 300 genů
• Kompatibilita se sekvenátory Illumina a AVITI
• Inovativní protokol InniSeq umožňuje uživatelům poolovat vzorky hned po prvním kroku. Šetří čas i spotřebovaný plast a minimalizuje vznik lidské chyby.
• Celková doba přípravy: 190 minut

  1. Panel annealing: 2:10 hrs

  2. Target extension: 10 min

  3. Exonuclease: 15 min

  4. Barcoding: 35 min

  5. Clean up: 20 min

1. Oncology Panels

Tissue Specific Panel

Bladder Cancer Panel, Expanded BRCA Panel, Colorectal and Pancreatic Cancer Panel, Gastric and Esophageal Cancer Panel, Gynecological Cancer Panel, HRR Pathway Panel, Kidney Cancer Panel, Liver Cancel Panel, Lymphoma Cancer Panel, Melanoma Panel, Prostate Panel

Comprehensive Tumor Panel

Gene list: AKT3, ALK, APC, AR, ARID1A*, ATM, ATR, BAP1, BARD1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BRIP1, BTK, CARD11, CCND1, CCND2, CCND3*, CCNE1*, CD79A*, CD79B, CDH1, CDK12, CDK4, CDK6, CDKN2A, CEBPA*, CHEK1, CHEK2*, CREBBP*, CSF1R, CTNNB1, DDR2, DNMT3A*, EGFR, EP300, ERBB2, ERBB3, ERBB4, ERCC1, ERCC2, ERG, ESR1, EZH2, FAM175A, FANCI, FANCL, FBXW7, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4*, FGF5, FGF6, FGF7, FGF8*, FGF9, FGFR1, FGFR2, FGFR3*, FGFR4, FLT1, FLT3, FOXL2, GEN1, GNA11, GNAQ, GNAS*, HNF1A, HRAS, IDH1, IDH2, INPP4B, JAK2, JAK3, KDR, KIT, KRAS*, LAMP1, MAP2K1, MAP2K2, MCL1, MDM2, MDM4, MET, MLH1, MLL*, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL1, MYCN*, MYD88, NBN, NF1, NOTCH1*, NOTCH2, NOTCH3*, NPM1, NRAS, NRG1, PALB2, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PMS2, PPP2R2A, PTCH1, PTEN, PTPN11, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, RET, RICTOR, ROS1, RPS6KB1, SLX4, SMAD4, SMARCB1, SMO, SRC, STK11, TERT, TET2, TFRC, TP53, TSC1, TSC2, VHL, XRCC2​

Short Oncology Panel

Gene list:NRAS G12, G13, Q61, K117, A146; KRAS G12, G13, Q61,K117, A146; BRAF V600 EGFR Exons: 18, 19, 20, 21; PIK3CA Exons: 1, 9, 20

2. Hematology Panels

Myeloid Malignancies Panel

Gene list: ASXL1*, BCOR, BCORL1, BRAF*, BRCC3, CALR*, CBL*, CEBPA, CSF1R*, CSF3R*, DDX41*, DNMT3A, ETV6*, EZH2, FLT3 TKD*, FLT3_ITD*, GATA2*, GNAS*, GNB1*, IDH1*, IDH2*, JAK2*, KDM6A, KIT*, KRAS*, MPL*, NF1, NPM1*, NRAS*, PDS5B, PHF6, PPM1D*, PTPN11*, RAD21, RUNX1, SETBP1*, SF3B1*, SMC1A*, SMC3, SRSF2*, STAG2, TET2, TP53, U2AF1*, WT1, ZNF687*, ZRSR2​

Diffuse Large B-Cell Lymphoma Panel

Gene list:ACTB, ACTG1, ANKRD11, ARID1A, ARID1B, B2M, BCL10, BCL2, BCL6, BCL7A, BCOR, BTG1, BTG2, C4B_2, CARD11, CCND3, CD58, CD70, CD79B, CIITA, CREBBP, DAZAP1, DTX1, DUSP2, EP300, EBF1, ETS1, EZH2, FAS, FOXO1, GNA13, GNAI2, GRHPR, HLA-A, HLA-B, HLA-C, HIST1H1B, HIST1H1C, HIST1H1D, HIST1H2AC, HIST1H2AM, HIST1H1E, ITPKB, IRF2BP2, IRF4, IRF8, KLHL14, KLHL6, KLF2, KMT2D, LTB, MEF2B, MPEG1, MYC, MYD88, NFKBIE, NOTCH2, OSBPL10, P2RY8, PAX5, PIM1, PIM2, PLEC, PRDM1, SETD1B, SGK1, SOCS1, SPEN, STAT3, TBL1XR1, TET2, TMSB4X, TNFAIP3, TNFRSF14, TOX, TP53, TRIOBP, TTN, UBE2A, VMP1, WDFY4, ZC3H12A, ZEB2, ZFP36L1

B-Cell Clonality Panel

3. Custom tailored panels

4. Bioinformatic analysis pipeline